• Newly Developed Light-Responsible Fluorogenic Bioorthogonal Reaction A Tool For Chemical Biology
    Advanced Science
    On May 2nd, Advanced Science published a collaborative study from Drs. Liu Jia, Jiang Biao Laboratories of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Dr. Jiang Xianxing from the School of Pharmaceutical Science at Sun Yat-Sen University, entitled “Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction”. Their study devel...
  • New Research Develops Pan-Coronavirus Fusion Inhibitor
    Science Advances
    A team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from ShanghaiTech’s SIAIS and Dr. Lu Lu and Dr. Jiang Shibo from Fudan University’s School of Basic Medical Sciences have developed a pan-coronavirus (pan-CoV) fusion inhibitor EK1. EK1 targets the HR1 domains of various human coronavirus (HCoV) spike (S) proteins to prevent the host-HCoV membrane fusion process and inhibits the host...
  • HiPSCs Microfluidic Reprogramming Success Advances Clinical Application
    Nature Protocols
    Human induced pluripotent stem cells (hiPSCs) are embryonic-like stem cells derived from adult somatic cells by a reprogramming process. They have a number of potential applications in stem cell biology and regenerative medicine, including precision medicine. However, their potential clinical application is hampered by the low efficiency, high costs, and heavy workload of the reprogramming process...
  • SIAIS Hosts 5th ShanghaiTech-SIAIS Bioforum
    The 5th ShanghaiTech-SIAIS Bioforum was successfully held November 13th to 16th at ShanghaiTech University, with the theme of “Advances in Integrative Biology of Cellular Processes.” The main topic discussed was breakthrough Technological Advances in Protein Research (Cryo-EM, Optogenetics, DNA-encoded Chemical Libraries). Over 500 attendees from universities, research institutions and corp...
  • Reveal of New Electron Transfer Mechanism Advances Anti-Tuberculosis Drug R&D
    On October 25th, ShanghaiTech Distinguished Professor-in-Residence Rao Zihe and his team’s research on “An electron transfer path connects subunits of a mycobacterial respiratory supercomplex” was published online in Science journal.On the strength of cryo-electron microscopy (cryo-EM) with high resolution (3.5 Å) structure of mycobacterial respiratory supercomplex, the team revealed a new...
  • Groundbreaking Study Offers New Entry Point in Triple Negative Breast Cancer Research
    Journal of Molecular Cell Biology
    Recently, SIAIS’s Stem Cell Biology Lab has revealed a new mechanism of Wnt/β-catenin signaling pathway activation in triple-negative breast cancer, which was published as a cover story in Journal of Molecular Cell Biology with the title "MiR-221/222 activate the Wnt/beta-catenin signaling to promote triple negative breast cancer."Breast cancer is the most invasive type of cancer ...
  • Methods and Protocols in Cutting-Edge ZFP Research Covered in New Volume
    Methods in Molecular Biology
    Research Associate Professor Liu Jia from SIAIS Professor Jiang Biao’s ADC Chemistry Lab has completed editing the 1867 volume of Methods in Molecular Biology (MiMB) with titled “Zinc Finger Proteins: Methods and Protocols,” now available from Springer, Amazon and other booksellers.The MiMB series, providing methods and protocols in molecular biology, was founded by editor John Walker in 1...
  • SIAIS Scientific Governing Board Member Shares Nobel Prize
    The 2018 Nobel Prize in Chemistry was announced on October 3rd.  The winners for this year are Frances H. Arnold (USA), George P. Smith (USA) and Sir Gregory P. Winter (UK). Frances Arnold shares half of the prize for her research "for the directed evolution of enzymes." George Smith and Gregory Winter share the other half of the prize for their research "for the phage display ...
  • Highly Specific Antibody Could Help Fight Against Neurological Diseases
    A research collaboration between the laboratories of Yang Guang and Richard Lerner of SIAIS in ShanghaiTech University and the laboratory of Xu Tianle in Shanghai Jiao Tong University School of Medicine has led to an article published in the Proceedings of the National Academy of Sciences of the United States of America on July 25th. The article, “Selection of an ASIC1a-blocking combina...
  • New Progress on Zika Virus Elucidites Role of AXL in Promoting ZIKV Infection
    Nature Microbiology
    Nature Microbiology recently made available as an Advance Online Publication the research findings of a collaboration between SIAIS Research Associate Professor Liu Jia from the Laboratory of ADC Chemistry and Professor Xu Jianqin from Fudan University Shanghai Public Health Clinical Center on new progress on Zika virus, elucidating the role of AXL in promoting Zika virus (ZIKV) infection.ZIK...
  • Novel Anti-Cancer Drug R&D and Licensing Collaboration Announced
    ShanghaiTech University and Jing Medicine Technology (Shanghai) Ltd. announced an over $100 million USD strategic collaboration to discover and develop novel small molecule anti-cancer drugs. Under the terms of the agreement, Jing Medicine will receive global development and commercialization rights of anti-cancer molecules resulting from the collaboration with ShanghaiTech University. ShanghaiTec...
  • SIAIS Hosts 2017 BioForum
    SIAIS hosted a successful 2017 ShanghaiTech-SIAIS BioForum at ShanghaiTech’s brand-new conference center from November 13th to 16th.In the opening ceremony, ShanghaiTech Vice President and Provost Yin Jie and chairman of 2017 BioForum and BBRC editor Professor Ernesto Carafoli delivered opening addresses. Yin Jie welcomed the guests and introduced ShanghaiTech’s development, current situati...
  • Acid-labile Molecular Container for Controlled Drug Release Developed
    Angewandte Chemie
    In a recent study, Research Associate Professor Liu Jia from SIAIS and Professor Ma Da from Fudan University developed an acid-labile acyclic cucurbit[n]uril (CB[n]) molecular containers for controlled drug release. Their study was published in Angewandte Chemie International Edition.Pathological conditions such as tumors often lead to acidic microenvironment, making acid-labile drug carriers attr...